PROPERTIES AND USE OF MICROREACTORS Introduction Physical Characteristics of Microreactors Fluid Flow and Delivery Regimes Multifunctional Integration Uses of Microreactors
FABRICATION OF MICROREACTORS MADE FROM METALS AND CERAMIC Manufacturing Techniques for Metals Etching Machining Generative Method: Selective Laser Melting Metal Forming Techniques Assembling and Bonding of Metal Microstructures Ceramic Devices Joining and Sealing
MICROREACTORS MADE OF GLASS AND SILICON How Microreactors Are Constructed The Structuring of Glass and Silicon Isotropic Wet Chemical Etching of Silicon Other Processes Thin Films Bonding Methods Other Materials
AUTOMATION IN MICROREACTOR SYSTEMS Introduction Automation System Automated Optimization with HPLC Sampling Automated Multi-Trajectory Optimization Kinetic Model Discrimination and Parameter Fitting Conclusions and Outlook
HOMOGENEOUS REACTIONS Acid-Promoted Reactions Base-Promoted Reactions Radical Reactions Condensation Reactions Metal-Catalyzed Reactions High Temperature Reactions Oxidation Reactions Reaction with Organometallic Reagents
HOMOGENEOUS REACTIONS II: PHOTOCHEMISTRY AND ELECTROCHEMISTRY AND RADIOPHARMACEUTICAL SYNTHESIS Photochemistry in Flow Reactors Electrochemistry in Microreactors Radiopharmaceutical Synthesis in Microreactors Conclusion and Outlook
HETEROGENEOUS REACTIONS Arrangement of Reactors in Flow Synthesis Immobilization of the Reagent/Catalyst Flow Reactions with an Immobilized Stoichiometric Reagent Flow Synthesis with Immobilized Catalysts: Solid Acid Catalysts Flow Reaction with an Immobilized Catalyst: Transition Metal Catalysts Dispersed on Polymer Flow Reaction with an Immobilized Catalyst: Metal Catalysts Coordinated by a Polymer-Supported Ligand Organocatalysis in Flow Reactions Flow Biotransformation Reactions Catalyzed by Immobilized Enzymes Multistep Synthesis Conclusion
LIQUID - LIQUID BIPHASIC REACTIONS Introduction Background Kinetics of Biphasic Systems Biphasic Flow in Microchannels Surface and Liquid - Liquid Interaction Liquid - Liquid Microsystems in Organic Synthesis Micromixer Conclusions and Outlook
GAS - LIQUID REACTIONS Introduction Contacting Principles and Microreactors Gas - Liquid Reactions Gas - Liquid - Solid Reactions Homogeneously Catalyzed Gas - Liquid Reactions Other Applications Conclusions and Outlook
BIOORGANIC AND BIOCATALYTIC REACTIONS General Introduction Bioorganic Syntheses Performed in Microreactors Biocatalysis by Enzymatic Microreactors Multienzyme Catalysis in Microreactors Conclusions
INDUSTRIAL MICROREACTOR PROCESS DEVELOPMENT UP TO PRODUCTION Mission Statement from Industry on Impact and Hurdles Screening Studies in Laboratory Process Development at Laboratory Scale Pilot Plants and Production Challenges and Concerns
For the second edition of 'Microreactors in Organic Chemistry and Catalysis' all chapters have been revised and updated to reflect the latest developments in this rapidly developing field. This new edition has 60% more content, and it remains a comprehensive publication covering most aspects of the topic. The use of microreactors in homogeneous, heterogeneous as well as biphasic reactions is covered in the main part of the book, together with catalytic, bioorganic and automation approaches. The initial chapters also provide a solid physical chemistry background on fluidics in microdevices. Finally, a chapter on industrial applications and developments covers recent progress in process chemistry. An excellent reference for beginners and experts alike.
Thomas Wirth is professor of organic chemistry at Cardiff University. After studying chemistry in Bonn and at the Technical University of Berlin, he obtained his PhD in 1992 with Professor S. Blechert. After a postdoctoral stay with Professor K. Fuji at Kyoto University as JSPS fellow, he started his independent research at the University of Basel (Switzerland). In the group of Professor B. Giese he obtained his habilitation on stereoselective oxidation reactions supported by various scholarships before taking up his current position at Cardiff University in 2000. He was invited as a visiting professor to a number of places including the University of Toronto/Canada (1999), various universities in Japan including Chuo University (2000), Osaka University (2004), Osaka Prefecture University (2008) and Kyoto University (2012, with a JSPS short term fellowship). He was awarded the Werner-Prize from the New Swiss Chemical Society in 2000. His main interests of research concern stereoselective electrophilic reactions, oxidative transformations with hypervalent iodine reagents including mechanistic investigations and organic synthesis performed in microreactors.
